Detailed view for PF3D7_0317500

Basic information

TDR Targets ID: 3672
Plasmodium falciparum, kinesin-5
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.7588 | Length (AA): 1619 | MW (Da): 191785 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00225   Kinesin motor domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005871   kinesin complex  
GO:0008017   microtubule binding  
GO:0005524   ATP binding  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 489 1goj (A) 3 337 42.00 0 1 0.32 0.52
408 506 2kin (B) 252 351 47.00 0.000000000011 0.97 0.62 -0.39
9 506 1mkj (A) 3 349 46.00 0 1 0.300797 0.76
15 489 2vvg (A) 5 342 50.00 0 1 0.227591 0.75
16 493 3zfd (A) 10 348 40.00 0 1 0.245844 0.62
56 479 3dc4 (A) 43 317 36.00 0.00035 1 -0.17551 1.7
273 475 1f9t (A) 511 716 48.00 0 0.89 0.470586 0.53
680 927 4tql (A) 9 228 25.00 0.96 1 0.343381 -0.01
898 1261 4wat (A) 147 492 29.00 0.11 0.33 0.16303 1.14
1224 1509 4u0r (A) 163 502 17.00 0.29 0.03 0.300252 -0.58
1283 1605 4hte (A) 256 577 18.00 0.045 0.05 0.302106 -0.05
56 479 3dc4 (A) 43 317 36.00 0.005 1 -0.187794 1.82
539 782 4tql (A) 10 238 16.00 0.011 0.18 0.214921 -0.07
964 1157 1fyh (A) 32 313 26.00 0.13 0.62 0.354275 -0.2
1136 1394 4u0r (A) 183 498 15.00 0.2 0.11 0.246444 -0.56
1376 1560 4uos (A) 2 184 11.00 0.75 0.05 0.34566 -1.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, early schizont, late schizont, late trophozoite, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, early trophozoite, late ring, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128460)

Species Accession Gene Product
Arabidopsis thaliana AT2G36200   kinesin family protein
Arabidopsis thaliana AT2G28620   kinesin motor protein-related protein
Arabidopsis thaliana AT2G37420   ATP binding microtubule motor family protein
Arabidopsis thaliana AT3G45850   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Brugia malayi Bm1_27915   Kinesin motor domain containing protein
Candida albicans CaO19.712   kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein
Candida albicans CaO19.8331   kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein
Caenorhabditis elegans CELE_F23B12.8   Protein BMK-1, isoform B
Cryptosporidium hominis Chro.60483   kinesin-like boursin
Cryptosporidium parvum cgd6_4210   kinesin-like boursin, putative
Dictyostelium discoideum DDB_G0288361   kinesin family member 13
Drosophila melanogaster Dmel_CG9191   Kinesin-like protein at 61F
Echinococcus granulosus EgrG_001180200   kinesin family 1
Entamoeba histolytica EHI_124890   kinesin, putative
Echinococcus multilocularis EmuJ_001180200   kinesin family 1
Giardia lamblia GL50803_16425   Kinesin-5
Homo sapiens ENSG00000138160   kinesin family member 11
Loa Loa (eye worm) LOAG_04424   kinesin-like protein KLP2
Mus musculus ENSMUSG00000012443   kinesin family member 11
Neospora caninum NCLIV_006210   hypothetical protein
Oryza sativa 9268593   Os05g0117798
Oryza sativa 9271005   Os08g0558400
Plasmodium berghei PBANKA_0807700   kinesin-5, putative
Plasmodium falciparum PF3D7_0317500   kinesin-5
Plasmodium knowlesi PKNH_0824300   kinesin-5, putative
Plasmodium vivax PVX_095355   kinesin-5
Plasmodium yoelii PY02733   Kinesin motor domain, putative
Saccharomyces cerevisiae YBL063W   Kip1p
Schistosoma japonicum Sjp_0035130   ko:K10398 kinesin family member 11, putative
Schistosoma mansoni Smp_149260   kinesin eg-5
Schmidtea mediterranea mk4.002094.08  
Toxoplasma gondii TGME49_297110   kinesin motor domain-containing protein

Essentiality

PF3D7_0317500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_297110 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.9

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens kinesin family member 11 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0317500 (Plasmodium falciparum), kinesin-5
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